Effect of Verapamil, Cinnarizine and Memantine on Maximal Electroshock, Picrotoxin, and Pilocarpine-Induced Seizure Models in Albino Mice
نویسندگان
چکیده
منابع مشابه
The effect of simvastatin on picrotoxin-induced seizure in mice.
OBJECTIVE To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death. METHODS The study was held between July and September 2011, at the Karadeniz Technical University in Trabzon, Turkey. Balb/c mice weighting 20-40g were randomly selected and divided into five groups of six each. The first group was de...
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The effects of Tilia plathphyllos scop. in a nervous disorder, including seizure was reported in traditional literatures. In the present investigation, the effects of methanolic extract of T. plathyphyllos on seizure induced by picrotoxin and pentylentetrazole were studied in mice. In this experimental study, groups of 5 animals pretreated with doses of 100, 200 and 300 mg/kg of methanolic extr...
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Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in a seizure model. Methods: Seizures were induced in male adult Swiss mice by administration of pentylenetetrazol (PTZ) or Maximal Electroshock (MES). Mice were randomly subjected to receive saline, EFA (8.75-175 mg.kg-1), or d...
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The anticonvulsant effect of cannabinoid compound has been shown in various models of seizure. On the other hand, there are controversial findings about the role of large conductance calcium-activated potassium (BK) channels in the pathogenesis of epilepsy. In this study, the effect of arachidonyl-2′-chloroethylamide (ACEA), a CB1 receptor agonist, and a BK channel antagonist, paxilline, either...
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Introduction: Jugulans regia (Jugulandaceae), Astragaus hamosus (Papilionaceae), Crocus pallasii subsp. haussknechtii boiss. (Iridaceae) and Cassia angustifolia Vahl. (Caesalpinaceae) have been suggested as antiepileptic remedies in traditional medicine of Iran. The possible anticonvulsant effect of the hydroalcoholic extract of the leaves of J. regia, fruits of A. hamosus, corm of C. haussk...
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ژورنال
عنوان ژورنال: Egyptian Journal of Basic and Clinical Pharmacology
سال: 2015
ISSN: 2090-7230,2090-7222
DOI: 10.11131/2015/101356